follicle-stimulating hormone [FSH]-beta chain; follitropin beta chain (FSHB, Follistim)

Function

• stimulates development of follicle & spermatogenesis in the reproductive organs

Structure

• heterodimer of a common alpha chain (glycoprotein hormone alpha) & a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin & gonadotropin
• belongs to the glycoprotein hormones subunit beta family

Compartment

secreted

Pathology

• defects in FSHB are a cause of isolated FSH deficiency

Pharmacology

• available as Follistim

Laboratory

• FSHB gene mutation

More general terms

• glycoprotein hormone-beta chain
• endocrine agent

More specific terms

• urofollitropin (puregon, serono, organon, FSH-beta, Fertinex, Metrodin, Bravelle)

Additional terms

• follicle-stimulating hormone (FSH) in serum

Component of

• follicle-stimulating hormone; follitropin (FSH)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2488
• OMIM: https://mirror.omim.org/entry/136530
• OMIM: https://mirror.omim.org/entry/229070
• UniProt: http://www.uniprot.org/uniprot/P01225.html