proteoglycan 3 (eosinophil major basic protein homolog, prepro-major basic protein homolog, prepro-MBPH, PRG3, MBPH, UNQ486/PRO1002)

Function

• similar cytotoxic & cytostimulatory activities to PRG2/MBP
• in vitro, stimulates neutrophil superoxide production & IL8 release, & histamine & leukotriene C4 release from basophils

Structure

contains 1 C-type lectin domain

Compartment

localized to eosinophil secondary granule

Expression

• expressed in bone marrow
• not detected in placenta

More general terms

• proteoglycan core protein

Database

• OMIM: https://mirror.omim.org/entry/606814
• UniProt: http://www.uniprot.org/uniprot/Q9Y2Y8.html