pantetheinase (pantetheine hydrolase, vascular non-inflammatory molecule 1, Vanin-1, Tiff66, VNN1)

Function

• amidohydrolase
• hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) & releasing cysteamine

(R)-pantetheine + H2O <--> (R)-pantothenate + cysteamine

Structure

• belongs to the CN hydrolase family, BTD/VNN subfamily
• contains 1 CN hydrolase domain

Compartment

cell membrane, GPI-anchor

Expression

• expressed in spleen, thymus, peripheral blood lymphocytes, small intestine

More general terms

• amidohydrolase
• glypiated protein

Database

• OMIM: https://mirror.omim.org/entry/603570
• UniProt: http://www.uniprot.org/uniprot/O95497.html