biotinidase; biotinase; (BTD)

Function

• catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation

biotin amide + H2O <--> biotin + NH3

Structure

• N-glycosylated
• belongs to the CN hydrolase family, BTD/VNN subfamily
• contains 1 CN hydrolase domain

Compartment

secreted, extracellular space

Pathology

• defects in BTD are the cause of biotinidase deficiency

More general terms

• hydrolase
• secreted protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P43251.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=686
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:686
• OMIM: https://mirror.omim.org/entry/253260
• OMIM: https://mirror.omim.org/entry/609019