biotin (vitamin B7, vitamin H)
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Epidemiology
- biotin is present in food protein bound or as biocytin
Function
- coenzyme in the metabolism of fatty acids & leucine
- role in gluconeogenesis
- role in the citric acid cycle
- functions in the transfer carbon dioxide
- cofactor in several carboxylases:
Pathology
- avidin in egg whites binds to biotin rendering it unavailable
- avidin is denatured by heat
- biotin deficiency is rare
Dosage
- recommended daily allowance is 3 ug/day
- up to 300 mg/day has been prescribed for multiple sclerosis[2]
Test interactions
- high intake make result in falsely low serum troponin[2]
- interference with thyroid function tests with biotin > 5-10 mg/day
More general terms
Additional terms
Component of
- biotin/panthenol/shampoo
- biotin/nicotinamide/panthenol/shampoo/zinc pyrithione
- biotin/nad/panthenol/shampoo/zinc pyrithione
- biotin/chromium picolinate
- ascorbate/biotin/ferrous fumarate/folic acid/methylcobalamin/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
- ascorbate/biotin/calcium carbonate/cobalamin/folic acid/iron dextran/nicotinic acid/pantothenate/pyridoxine/riboflavin/succinate/thiamine
- ascorbate/biotin/ca+2/cobalamin/folic acid/nicotinic acid/pantothenate/pyridoxine/riboflavin/thiamine
- ascorbate/biotin/ca+2/cobalamin/folic acid/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
- ascorbate/biotin/ca+2/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium sulfate/manganese sulfate/nicotinic acid/pantothenate/polysaccharide iron complex/pyridoxine/riboflavin/thiamine/zinc sulfate
- alpha tocopherol/ascorbate/biotin/cobalamin/ergocalciferol/folic acid/multivitamin/nicotinamide/panthenol/phytonadione/pyridoxine/riboflavin/thiamine/vitamin a
- alpha tocopherol/ascorbate/biotin/cholecalciferol/cobalamin/folic acid/nicotinamide/palmitate/panthenol/phytonadione/pyridoxine/riboflavin/thiamine/vitamin a
- biotin/nicotinamide/panthenol/zinc pyrithione
- biotin/nad/panthenol/zinc pyrithione
- biotin/cysteine/silicon dioxide
- biotin/cysteine/silicon
- biotin/chromium/chromium picolinate
- ascorbate/biotin/ferrous fumarate/folic acid/iron/methylcobalamin/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
- ascorbate/biotin/cobalamin/folic acid/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
- ascorbate/biotin/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium sulfate/manganese sulfate/nicotinic acid/pantothenate/polysaccharide iron complex/pyridoxine/riboflavin/thiamine/zinc sulfate
- ascorbate/biotin/cholecalciferol/cobalamin/folic acid/nicotinic acid/pantothenate/pyridoxine/riboflavin/thiamine
- ascorbate/biotin/calcium carbonate/cobalamin/ferrous fumarate/folic acid/magnesium oxide/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/vitamin a/vitamin e/zinc oxide
- ascorbate/biotin/calcium carbonate/cobalamin/ferrous fumarate/folic acid/magnesium oxide/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/vitamin a/vitamin e/zinc/zinc oxide
- ascorbate/biotin/calcium carbonate/cobalamin/dextran/folic acid/iron dextran/nicotinic acid/pantothenate/pyridoxine/riboflavin/thiamine
- alpha tocopheryl acetate/ascorbate/biotin/carbonyl iron/cobalamin/folic acid/sodium docusate
- alpha tocopheryl acetate/ascorbate/biotin/carbonyl iron/cobalamin/copper sulfate/folic acid/sodium docusate
- alpha tocopherol/ascorbate/biotin/cholecalciferol/cobalamin/folic acid/nicotinamide/panthenol/pyridoxine/riboflavin/thiamine/vitamin a/vitamin k
- alpha tocopherol/ascorbate/biotin/biotin/cobalamin/ergocalciferol/folic acid/multivitamin/nicotinamide/panthenol/pyridoxine/riboflavin/thiamine/vitamin a/vitamin k
- ascorbate/biotin/cobalamin/folic acid/nicotinic acid/pantothenate/pyridoxine/riboflavin/thiamine
References
- ↑ Wikipedia: Biotin http://en.wikipedia.org/wiki/Biotin
- ↑ 2.0 2.1 2.2 FDA MedWatch Nov 28, 2017 Biotin (Vitamin B7): Safety Communication - May Interfere with Lab Tests. https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm586641.htm
FDA Safety Communcation. Nov 5, 2019
UPDATE: The FDA Warns that Biotin May Interfere with Lab Tests: https://www.fda.gov/medical-devices/safety-communications/update-fda-warns-biotin-may-interfere-lab-tests-fda-safety-communication
Biotin Interference with Troponin Lab Tests - Assays Subject to Biotin Interference. https://www.fda.gov/medical-devices/vitro-diagnostics/biotin-interference-troponin-lab-tests-assays-subject-biotin-interference - ↑ 3.0 3.1 Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022