intelectin-1 (intestinal lactoferrin receptor, galactofuranose-binding lectin, endothelial lectin HL-1, omentin, ITLN1, INTL, ITLN, LFR, UNQ640/PRO1270)

Function

• role in the defense system against microorganisms (putative)
• may specifically recognize carbohydrate chains of pathogens & bacterial components containing galactofuranosyl residues (Ca+2-dependent)
• role in iron metabolism (putative)

Structure

• homotrimer, disulfide-linked
• N-glycosylated
• contains 1 fibrinogen C-terminal domain

Compartment

• cell membrane, GPI-anchor
• secreted

Expression

• expressed in the small intestine > heart, testis, colon, salivary gland, skeletal muscle, pancreas, thyroid > uterus, spleen, prostate, lymph node, thymus
• found in fetal small intestine & thymus

Genetics

• two mouse genes Itln1a & Itln1b are paralogs of human ITLN1

More general terms

• glypiated protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WWA0.html