acidic leucine-rich nuclear phosphoprotein 32 member B; PHAPI2 protein; silver-stainable protein SSP29; acidic protein rich in leucines; HLA-DR-associated protein I-2 (ANP32B, APRIL, PHAPI2)
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Function
- multifunctional protein
- cell cycle progression factor
- cell survival factor
- required for progression from G1 to S phase
- anti-apoptotic protein
- functions as a caspase-3 inhibitor
- has no phosphatase 2A (PP2A) inhibitor activity (putative)
- has histone chaperone properties
- stimulates core histones to assemble into a nucleosome
- some glutamate residues are glycylated by TTLL8
- glycylation occurs exclusively on glutamate residues & results in a glycine chain on the gamma-carboxyl group (putative)
- interacts with histones H3 & H4
Structure
- monomer
- histone binding is mediated by the concave surface of the LRR region
- belongs to the ANP32 family,
- contains 4 LRR repeats (leucine-rich repeats)
- contains 1 LRRCT domain
Compartment
- isoform 1: nucleus; accumulates in nuclei in S phase
- isoform 2: cytoplasm; lacks a nuclear localization signal
Alternative splicing
named isoforms=2