diacylglycerol kinase kappa; diglyceride kinase kappa; DGK-kappa; DAG kinase kappa; 142 kD diacylglycerol kinase (DGKK)

Function

• phosphorylates diacylglycerol, generates phosphatidic acid
• phosphorylated at Tyr-78 SRC family protein in response to H2O2

   ATP + 1,2-diacylglycerol
             <-->
ADP + 1,2-diacyl-sn-glycerol 3-phosphate

Inhibition:

• inhibited in response to H2O2

Structure

• belongs to the eukaryotic diacylglycerol kinase amily
• contains 1 DAGKc domain
  • contains 1 PH domain
  • contains 2 phorbol-ester/DAG-type zinc fingers

Compartment

cytoplasm, peripheral membrane

Expression

• expressed in testis > placenta

More general terms

• diacylglycerol kinase
• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5KSL6.html