palmitoyltransferase ZDHHC15 (zinc finger DHHC domain-containing protein 15, DHHC-15, ZDHHC15)

Function

• palmitoyltransferase specific for GAP43 & DLG4/PSD95
• DHHC domain required for palmitoyltransferase activity
• autopalmitoylated

palmitoyl-CoA + protein-cysteine <--> S-palmitoyl protein + CoA

Structure

• belongs to the DHHC palmitoyltransferase family.
• contains 1 DHHC-type zinc finger

Compartment

membrane, endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• expressed in placenta, liver, lung, kidney, heart, brain

Pathology

• defects in ZDHHC15 may be a cause of X-linked mental retardation 91 (MRX91)

More general terms

• acyltransferase
• zinc finger protein
• transmembrane 4 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96MV8.html