zinc finger protein Rlf; rearranged L-myc fusion gene protein; Zn-15-related protein (RLF)

Function

• may be involved in transcriptional regulation
• interacts with RIT1 & RIT2 (putative)

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 14 C2H2-type Zn+2 fingers

Compartment

nucleus (probable)

Expression

• widely expressed in fetal & adult tissues

Pathology

• in some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at 1p32 (rearrangement 1p32 RLF with L-MYC) fusing the first exon of the RLF gene with L-myc

More general terms

• C2H2 type zinc finger protein
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6018
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6018
• OMIM: https://mirror.omim.org/entry/180610
• UniProt: http://www.uniprot.org/uniprot/Q13129.html