zinc finger protein 373; palmitoyltransferase ZDHHC3; protein DHHC1; zinc finger DHHC domain-containing protein 3; DHHC-3 (ZDHHC3, ZNF373, HSD49)

Function

• palmitoyltransferase with broad specificity
• palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 & GABRG3), which regulates synaptic clustering &/or cell surface stability
• palmitoylates glutamate receptors GRIA1 & GRIA2, which leads to their retention in Golgi
• autopalmitoylated (putative)

palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

Structure

• the DHHC domain is required for palmitoyltransferase activity (putative)
• belongs to the DHHC palmitoyltransferase family
• contains 1 DHHC-type Zn+2 finger

Compartment

• Golgi membrane; multi-pass membrane protein (putative)

Alternative splicing

named isoforms=2

More general terms

• S-palmitoyl transferase
• zinc finger protein
• transmembrane 4 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51304
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51304
• UniProt: http://www.uniprot.org/uniprot/Q9NYG2.html