zinc finger protein 372; palmitoyltransferase ZDHHC2; reduced expression associated with metastasis protein; Ream; reduced expression in cancer protein; rec; zinc finger DHHC domain-containing protein 2; DHHC-2 (ZDHHC2, REAM, REC, ZNF372)

Function

• palmitoyltransferase specific for GAP43 & DLG4/PSD95

palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

Structure

• the DHHC domain is required for palmitoyltransferase activity (putative)
• belongs to the DHHC palmitoyltransferase family
• contains 1 DHHC-type Zn+2 finger

Compartment

membrane

Expression

• ubiquitously expressed
• reduced expression in colorectal cancers with liver metastasis

Pathology

• mutations in ZDHHC2 are found in hepatocellular carcinoma & colorectal cancer

More general terms

• S-palmitoyl transferase
• zinc finger protein
• transmembrane 4 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51201
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51201
• UniProt: http://www.uniprot.org/uniprot/Q9UIJ5.html