zinc finger protein 370; palmitoyltransferase ZDHHC7; zinc finger DHHC domain-containing protein 7; DHHC-7 (ZDHHC7, ZNF370)

Function

• palmitoyltransferase with broad specificity
• palmitoylates SNAP25 & DLG4/PSD95
• may palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 & GABRG3) & regulate their synaptic clustering &/or cell surface stability

palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

Structure

• the DHHC domain is required for palmitoyltransferase activity (putative)
• belongs to the DHHC palmitoyltransferase family
• contains 1 DHHC-type Zn+2 finger

Compartment

membrane

Alternative splicing

named isoforms=2

More general terms

• S-palmitoyl transferase
• zinc finger protein
• transmembrane 4 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55625
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55625
• UniProt: http://www.uniprot.org/uniprot/Q9NXF8.html