ubiquitin carboxyl-terminal hydrolase 27; deubiquitinating enzyme 27; ubiquitin carboxyl-terminal hydrolase 22-like; ubiquitin thiolesterase 27; ubiquitin-specific-processing protease 27; X-linked ubiquitin carboxyl-terminal hydrolase 27 (USP27X, USP22L, USP27)

Function

• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin

Structure

• belongs to the peptidase C19 family
• although strongly related to USP22, which deubiquitinates histones, lacks the N-terminal UBP-type Zn+2 finger, suggesting it does not have the ability to deubiquitinate histones

More general terms

• ubiquitin C-terminal hydrolase

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=389856
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:389856
• UniProt: http://www.uniprot.org/uniprot/A6NNY8.html