ariadne-1 protein homolog; ARI-1; ubiquitin-conjugating enzyme E2-binding protein 1; UbcH7-binding protein; UbcM4-interacting protein; HHARI; H7-AP2; monocyte protein 6; MOP-6 (ARIH1, ARI, MOP6, UBCH7BP, HUSSY-27)

Function

• might act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, & then transfers it to substrates
• interacts with UBE2L3

Structure

• belongs to the RBR family, Ariadne subfamily
• contains 1 IBR-type Zn+2 finger
• contains 2 RING-type Zn+2 fingers

Compartment

cytoplasm (mainly cytoplasmic)

Expression

widely expressed

More general terms

• ring finger protein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25820
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25820
• OMIM: https://mirror.omim.org/entry/605624
• UniProt: http://www.uniprot.org/uniprot/Q9Y4X5.html