neuroblastoma suppressor of tumorigenicity 1; zinc finger protein DAN; N03; DAN domain family member 1 (NBL1, DAN, DAND1)

Function

• may be tumor suppressor gene of neuroblastoma
• may play role in preventing cells from entering the final stage (G1/S) of the transformation process

Structure

• belongs to the DAN family
• contains 1 CTCK domain (C-terminal cystine knot-like)

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

most abundant in normal lung & meningioma

Pathology

• defects in NBL1 may cause of &/or enhance progression of human neuroblastoma

More general terms

• zinc finger protein
• secreted protein

Database

• UniProt: http://www.uniprot.org/uniprot/P41271.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4681
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4681
• OMIM: https://mirror.omim.org/entry/600613