5'-3' exoribonuclease 2 ( DHM1-like protein, DHP protein, XRN2)
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Function
- possesses 5'->3' exoribonuclease activity
- may promote the termination of transcription by RNA polymerase 2 (during transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA & a 3' fragment which remains attached to the elongating RNA polymerase 2; processive degradation of this 3' fragment by XRN2 may promote termination of transcription)
- exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates
Structure
- belongs to the 5'-3' exonuclease family, XRN2/RAT1 subfamily
- contains 1 CCHC-type Zn+2 finger
Compartment
Alternative splicing
named isoforms=2
Expression
- expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, & pancreas
- isoform 2 is expressed predominantly in peripheral blood leukocytes