rho guanine nucleotide exchange factor 9; Rac/Cdc42 guanine nucleotide exchange factor 9; collybistin; PEM-2 homolog (ARHGEF9, KIAA0424)

Function

• guanine nucleotide exchange factor (GEF) for CDC42
• promotes formation of GPHN cluster

Compartment

cytoplasm

Expression

expressed in brain & in low levels in heart

Pathology

• defects in ARHGEF9 are associated with:
  • startle disease with epilepsy

More general terms

• rho guanine nucleotide exchange factor

Database

• OMIM: https://mirror.omim.org/entry/300429
• UniProt: http://www.uniprot.org/uniprot/O43307.html