Rho guanine nucleotide exchange factor 5; ephexin-3; guanine nucleotide regulatory protein TIM; oncogene TIM; transforming immortalized mammary oncoprotein; p60 TIM (ARHGEF5, TIM)
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Structure
- contains 1 DH (DBL-homology) domain
- contains 1 PH domain
- contains 1 SH3 domain
Alternative splicing
named isoforms=2
Expression
Genetics
- a segmental duplication of chromosome 7 involving ARHGEF5 is one of the few features distinguishing the human genome from the chimpanzee genome[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q12774.html
- ↑ 2.0 2.1 Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour- Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM. Lineage-specific gene duplication and loss in human and great ape evolution. PLoS Biol. 2004 Jul;2(7):E207. Epub 2004 Jul 13. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15252450