ETS-related transcription factor Elf-5 (E74-like factor 5, epithelium-specific Ets transcription factor 2, ESE-2, epithelium-restricted ESE-1-related Ets factor, ELF5, ESE2)

Function

• transcriptional activator
• role in regulating later stages of keratinocytes terminal differentiation
• isoform 2 binds to DNA sequences containing consensus nucleotide core sequence GGA[AT]
• transcriptionally activates SPRR2A & parotid gland-specific PSP promoters

Structure

• belongs to the ETS family
• contains 1 ETS DNA-binding domain
• contains 1 PNT domain (pointed domain)
  • PNT domain acts as a transcriptional activator

Alternative splicing

named isoforms=3

Expression

• expressed in tissues with epithelial cells
• expressed in salivary gland, mammary gland, kidney, prostate > placenta, lung
• isoforms 1 & 2 are differentially expressed in different tissues
  • in kidney, only isoform 1 is expressed in prostate, isoform 2 > isoform 1
• expression is up-regulated during keratinocyte differentiation

Pathology

• several epithelial carcinoma cell lines lack expression

More general terms

• ETS-related transcription factor Elf
• DNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/605169
• UniProt: http://www.uniprot.org/uniprot/Q9UKW6.html