zinc finger protein basonuclin-1 (BNC1, BNC)

Function

• likely to be a transcription factor specific for squamous epithelium & for the constituent keratinocyte at a stage either prior to or at the very beginning of terminal differentiation
• may play a role in the differentiation of spermatozoa & oocytes
• phosphorylation on Ser-537 & Ser-541 leads to cytoplasmic localization

Structure

contains 6 C2H2-type Zn+2 fingers

Compartment

• nucleus (putative). cytoplasm
• elocates to the midpiece of the flagellum during late spermiogenesis in spermatids (putative)

Expression

• expressed in epidermis, testis & foreskin, & to a lower extent in thymus, spleen, mammary glands, placenta, brain & heart

More general terms

• DNA-binding protein
• C2H2 type zinc finger protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q01954.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=646
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:646
• OMIM: https://mirror.omim.org/entry/601930