C5-cytosine DNA methyltransferase-2; tRNA (cytosine-5-)-methyltransferase; DNA (cytosine-5)-methyltransferase-like protein 2; Dnmt2; DNA methyltransferase homolog HsaIIP; DNA MTase homolog HsaIIP; M.HsaIIP; PuMet (TRDMT1, DNMT2)

Function

• specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp)

S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine

Structure

belongs to the C5-methyltransferase family

Compartment

nucleus (probable)

Alternative splicing

• named isoforms=6
• additional isoforms seem to exist

Expression

• ubiquitous
• higher expression in testis, ovary & thymus
• expressed at much lower levels in spleen, prostate, colon, small intestine, & peripheral blood leukocytes

More general terms

• DNA-binding protein
• DNA (cytosine-5)-methyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1787
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1787
• OMIM: https://mirror.omim.org/entry/602478
• UniProt: http://www.uniprot.org/uniprot/O14717.html