nuclear factor of activated T-cells 5; NF-AT5; T-cell transcription factor NFAT5; Tonicity-responsive enhancer-binding protein; TonE-binding protein; TonEBP (NFAT5, KIAA0827, TONEBP)
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Function
- role in the inducible expression of genes
- regulates hypertonicity-induced cellular accumulation of osmolytes
- does not bind with Fos & Jun transcription factors
- might be capable of forming stable dimers with DNA elements
- stimulates macrophage secretion of the angiogenesis molecule VEGF-C[2]
Structure
contains 1 RHD (Rel-like) domain
Compartment
Alternative splicing
named isoforms=3; A, B, C
Expression
- highest levels in skeletal muscle, brain, heart & peripheral blood leukocytes
- also expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine & colon
- induced in macrophages in response to hypertonic conditions[2]
Pathology
- defects in macrophage NFAT5-stimulated VEGF-C secretion may play a role in salt-sensitive hypertension
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/O94916.html
- ↑ 2.0 2.1 2.2 Machnik A et al Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C dependent buffering mechanism. Nat Med 2009 May; 15:545 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19412173