Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3 (DKK3, REIC, UNQ258/PRO295)
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Function
- antagonizes canonical Wnt signaling by inhibiting LRP5 &/or LRP6
- interaction with Wnt & by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5 &/or LRP6
- DKKs play a role in vertebrate development, where they locally inhibit Wnt regulated processes such as anteroposterior axial patterning, limb development, somitogenesis & eye formation
- in adults, Dkks are implicated in bone formation
- interacts with LRP5 & LRP6 (putative)
Structure
- N-glycosylated & O-glycosylated
- the C-terminal cysteine-rich domain mediates interaction with LRP5 & LRP6 (putative)
- belongs to the dickkopf family
Compartment
Expression
- highest expression in heart, brain, & spinal cord
Pathology
- Dkks are implicated in bone disease, cancer & Alzheimer disease