insulin-like growth factor-binding protein 2; IBP-2; IGF-binding protein 2; IGFBP-2 (IGFBP2, BP2, IBP2)

Function

• IGF-binding proteins prolong the half-life of the IGFs
• they either inhibit or stimulate the growth promoting effects of the IGFs on cell culture
• they alter the interaction of IGFs with their cell surface receptors
• inhibits IGF-mediated growth & developmental rates
• binds IGF2 more than IGF1
• predominate form of IGF binding protein found in human & rat CSF & CNS is IGF-BP2 with 3 N-terminal amino acids truncated

Structure

• O-glycosylated
• C-terminus is required for IGF-binding & growth inhibition
• contains 1 IGFBP N-terminal domain
• contains 1 thyroglobulin type-1 domain

Compartment

secreted

More general terms

• insulin-like growth factor [IGF]-binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3485
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3485
• OMIM: https://mirror.omim.org/entry/146731
• UniProt: http://www.uniprot.org/uniprot/P18065.html