insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; placental protein 12; PP12 (IGFBP1, IBP1)
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Function
- IGF-binding proteins prolong the half-life of the IGFs
- they either inhibit or stimulate the growth promoting effects of the IGFs on cell culture
- they alter the interaction of IGFs with their cell surface receptors
- promotes cell migration
- phosphorylated, probably by casein kinase II
- phosphorylation alters the affinity of the protein for IGFs
- in amniotic fluid, the unmodified protein is the most abundant form
- mono-phosphorylated di-phosphorylated, tri-phosphorylated & tetra-phosphorylated forms are present in decreasing amounts
- phosphorylation state may influence the propensity to proteolysis
- binds equally well IGF1 & IGF2
Structure
- contains 1 IGFBP N-terminal domain
- contains 1 thyroglobulin type-1 domain
Compartment
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P08833.html
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/igfbp1/
- ↑ LeRoith et al, in: Insulin-like growth factors in the brain. Neurotrophic Factors, Academic Press 1993, pg 391
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3484