trypsin-1; beta-trypsin; cationic trypsinogen; serine protease 1; trypsin I; contains: alpha-trypsin chain 1, alpha-trypsin chain 2 (PRSS1, TRP1, TRY1, TRYP1)

Function

• has activity against the synthetic substrates
  • Boc-Phe-Ser-Arg-Mec
  • Boc-Leu-Thr-Arg-Mec
  • Boc-Gln-Ala-Arg-Mec
  • Boc-Val- Pro-Arg-Mec
• the single-chain form is more active than the two-chain form against all of these substrates
• preferential cleavage: Arg-|-Xaa, Lys-|-Xaa
• occurs in a single-chain form & a two-chain form, produced by proteolytic cleavage after Arg-122

Cofactor: binds 1 Ca+2 per subunit

Structure

• belongs to the peptidase S1 family
• contains 1 peptidase S1 domain

Compartment

• secreted, extracellular space

Pathology

• mutations associated with hereditary chronic pancreatitis

More general terms

• trypsin
• Ca+2 binding protein
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5644
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5644
• OMIM: https://mirror.omim.org/entry/167800
• OMIM: https://mirror.omim.org/entry/276000
• UniProt: http://www.uniprot.org/uniprot/P07477.html