A disintegrin & metalloproteinase with thrombospondin type 1 motif 14; ADAMTS-14; ADAM-TS 14; ADAM-TS14 (ADAMTS14)

Function

• aminoprocollagen type 1 processing activity in the absence of ADAMTS2
• seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity
• precursor is cleaved by a furin endopeptidase

Structure

• spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
• contains 1 disintegrin domain
• contains 1 peptidase M12B domain
• contains 1 PLAC domain
• contains 4 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix

Alternative splicing

Named isoforms=4

• C produced by alternative splicing of isoform B
• D produced by alternative splicing of isoform A Alternative promoter:
• A,B: produced by alternative promoter usage

Expression

• expressed in retina & at low levels in brain, lung & placenta
• high expression in fetal tissues

More general terms

• ADAMTS protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=140766
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:140766
• OMIM: https://mirror.omim.org/entry/607506
• UniProt: http://www.uniprot.org/uniprot/Q8WXS8.html