A disintegrin & metalloproteinase with thrombospondin type 1 motif 9; ADAMTS-9; ADAM-TS 9; ADAM-TS9 (ADAMTS9, KIAA1312)

Function

• cleaves the large aggregating proteoglycans, aggrecan & versican
• cleaves aggrecan at the 1838-Glu-|-Ala-1839 site & versican at the 1428-Glu-|-Ala-1429 site
• precursor is cleaved by a furin endopeptidase

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
• ancillary domains, including the TSRs domain, are required for specific extracellular localization & for its activity towards versican & aggrecan
• the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
• dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
• contains 1 disintegrin domain
• contains 1 GON domain
• contains 1 peptidase M12B domain
• contains 15 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Alternative splicing

named isoforms=3

Expression

• highly expressed in all fetal tissues
• expressed in a number of adult tissues with highest expression in heart, placenta & skeletal muscle

More general terms

• ADAMTS protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56999
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56999
• OMIM: https://mirror.omim.org/entry/605421
• UniProt: http://www.uniprot.org/uniprot/Q9P2N4.html