protein S100-A2; S100 Ca+2-binding protein A2; protein S-100L; CAN19 (S100A2, S100L)

Function

• may act as a modulator against excess Ca+2 accumulation in normal human mammary epithelial cells
• may also play a role in suppressing tumor cell growth
• binds 2 Ca+2

Structure

• belongs to the S-100 family
• contains 2 EF-hand domains

Expression

• expressed in a subset of epithelial cells including normal human mammary epithelial cells & keratinocytes
• preferentially expressed in normal human mammary epithelial cells as opposed to tumor-derived ones
• induced by growth factors in early G1 phase & probably by cell-cycle regulation in S phase
• DNA methylation probably plays a direct negative role in suppressing S100L gene expression in tumor cells

Pathology

• levels of S100L correlate inversely with breast cancer progression

More general terms

• S100 Ca+2-binding protein A

Additional terms

• S100 Ca+2-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/P29034.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6273
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6273
• OMIM: https://mirror.omim.org/entry/176993