NACHT, LRR & PYD-containing protein 10; nucleotide-binding oligomerization domain protein 8 (NALP10, NLRP10, NOD8, PYNOD)

Function

• inhibits CASP1/caspase-1-dependent IL1B secretion & PYCARD- mediated apoptosis, but not that induced by FAS or BID
• interacts with PYCARD, CASP1 & IL1B.

Structure

• oligomer
• contains 1 DAPIN domain contains 1 NACHT domain Despite name, it does NOT contain LRR repeats

Expression

• widely expressed with highest levels in heart, brain & skeletal muscle

More general terms

• NACHT, LRR & PYD-containing protein (NALP)

Database

• UniProt: http://www.uniprot.org/uniprot/Q86W26.html