NACHT, LRR & PYD-containing protein 6; PYRIN-containing APAF1-like protein 5 (NALP6, NLRP6, PYPAF5)

Function

• mediates activation of CASP1 via ASC & promote activation of NF-kappa-B (putative)
• binds to ASC with its DAPIN domain

Structure

• contains 1 DAPIN domain contains 5 LRR repeats (leucine-rich repeats) contains 1 NACHT domain

Compartment

cytoplasm

Expression

• highly expressed in granulocytes
• expressed at much lower levels in T-cells

More general terms

• NACHT, LRR & PYD-containing protein (NALP)

Database

• UniProt: http://www.uniprot.org/uniprot/P59044.html