WNT1-inducible-signaling pathway protein 3; WISP-3 (WISP3, CCN6, UNQ462/PRO790/PRO956)

Function

• appears to be required for normal postnatal skeletal growth & cartilage homeostasis

Structure

• belongs to the CCN family
• contains 1 CTCK (C-terminal cystine knot-like) domain
• contains 1 IGFBP N-terminal domain
• contains 1 TSP type-1 domain

Compartment

secreted (probable)

Expression

• predominant expression in adult kidney & testis & fetal kidney
• weaker expression found in placenta, ovary, prostate & small intestine
• also expressed in skeletally-derived cells such as synoviocytes & articular cartilage chondrocytes

Pathology

• defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood

More general terms

• WNT1 inducible signaling pathway protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8838
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8838
• OMIM: https://mirror.omim.org/entry/208230
• OMIM: https://mirror.omim.org/entry/603400
• UniProt: http://www.uniprot.org/uniprot/O95389.html