vacuolar protein sorting-associated protein 18 (hVPS18, VPS18, KIAA1475)

Function

• vesicle-mediated protein trafficking to lysosomal compartments
• membrane docking/fusion reactions of late endosomes/ lysosomes
• interacts with HOOK1, STX7
• component of arge hetero-oligomeric complex together with VPS11, VPS16 & VPS33A Comartment:
  • endosome, late endosomal membrane
  • lysosome, lysosomal membrane
  • cytoplasmic, peripheral membrane

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• expression in heart > lung

More general terms

• vacuolar protein sorting-associated protein (VPS)

Database

• OMIM: https://mirror.omim.org/entry/608551
• UniProt: http://www.uniprot.org/uniprot/Q9P253.html