thioredoxin domain-containing protein 2 (spermatid-specific thioredoxin-1, Sptrx-1, TXNDC2, SPTRX, SPTRX1)

Function

• regulatory role in sperm development
• regulation of fibrous sheath assembly by supporting formation of disulfide bonds during sperm tail morphogenesis
• may also be required to rectify incorrect disulfide pairing & generate suitable pairs between fibrous sheath constituents
• can reduce disulfide bonds in vitro in the presence of NADP & thioredoxin reductase

Structure

contains 1 thioredoxin domain

Compartment

• cytoplasm
• in ejaculated spermatozoa, localizes in the caudal region of the head to the end of the principal piece

Alternative splicing

named isoforms=2

Expression

• testis-specific
• only expressed during spermiogenesis
• prominent in round & elongating spermatids

More general terms

• thioredoxin domain-containing protein
• testis-specific protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86VQ3.html