peroxiredoxin-5, mitochondrial; peroxiredoxin V; Prx-V; peroxisomal antioxidant enzyme; PLP; thioredoxin reductase; thioredoxin peroxidase PMP20; antioxidant enzyme B166; AOEB166; TPx type VI; liver tissue 2D-page spot 71B; Alu corepressor 1 (PRDX5, ACR1, SBBI10)

Function

• reduces hydrogen peroxide & alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system
• involved in intracellular redox signaling

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH

Structure

• monomer
• belongs to the peroxiredoxin 2 family
• contains 1 thioredoxin domain

Compartment

• mitochondria, cytoplasm, peroxisome

Alternative initiation

• named isoforms=2
• mitochondrial
• cytoplasmic & peroxisomal

Expression

widely expressed

More general terms

• tperoxiredoxin (PRDX)
• mitochondrial protein

Additional terms

• thioredoxin-1 (TRX)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25824
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25824
• OMIM: https://mirror.omim.org/entry/606583
• UniProt: http://www.uniprot.org/uniprot/P30044.html