thioredoxin domain-containing protein 8 (spermatid-specific thioredoxin-3, Sptrx-3,thioredoxin-6, TXNDC8, SPTRX3, TRX6)

Function

• posttranslational modifications of proteins required for acrosomal biogenesis (putative)
• reduces disulfide bonds within the sperm (putative)

Structure

• belongs to the thioredoxin family
• contains 1 thioredoxin domain

Compartment

cytoplasm, Golgi

Alternative splicing

named isoforms=2

Expression

• testis-specific
• only expressed during spermiogenesis, prominently in Golgi of pachytenespermatocytes & round & elongated spermatids, with a transient localization in the developing acrosome of round spermatids

Pathology

• increased levels, possibly caused by overexpression, are observed in morphologically abnormal spermatozoa from infertile men

More general terms

• thioredoxin domain-containing protein
• testis-specific protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6A555.html