protein kinase A [PKA] catalytic subunit gamma (PRKACG)

Function

• enzyme catalytic subunit of protein kinase A (PKA)
• mediates cAMP-dependent signaling triggered by receptor binding to GPCRs
• PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation & regulation of microtubule dynamics, chromatin condensation & decondensation, nuclear envelope disassembly & reassembly, as well as regulation of intracellular transport mechanisms & ion flux
• cAMP facilitates formation free monomeric catalytic subunits (active form of protein kinase A)
• phosphorylates a large number of substrates in the cytoplasm & the nucleus

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family, cAMP subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 protein kinase domain

Expression

• testis specific?
• brain & ovary may have not been analyzed for the content of transcript

More general terms

• cAMP kinase
• testis-specific protein

Additional terms

• protein kinase A

Database

• UniProt: http://www.uniprot.org/uniprot/P22612.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5568
• OMIM: https://mirror.omim.org/entry/176893