autophagy 4 homolog C Cysteine protease ATG4C; EC=3.4.22.-; AUT-like 3 cysteine endopeptidase; autophagin-3; autophagy-related cysteine endopeptidase 3; autophagy-related protein 4 homolog C (ATG4C, APG4C, AUTL1, AUTL3)

Function

• cysteine protease required for autophagy
• cleaves C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I
• a subpopulation of form I is subsequently converted to a smaller form (form II)
• form II, with a revealed C-terminal GLY, is considered to be the phosphatidylethanolamine-conjugated form, & has the capacity for the binding to autophagosomes

Inhhibition:

• inhibited by N-ethylmaleimide

Structure

belongs to the peptidase C54 family

Compartment

cytoplasm (probable)

Expression

• highly expressed in skeletal muscle, heart, liver & testis

More general terms

• autophagy protein (autophagy-related protein)
• cysteine proteinase; thiol proteinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84938
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84938
• OMIM: https://mirror.omim.org/entry/611339
• UniProt: http://www.uniprot.org/uniprot/Q96DT6.html