autophagy 4 homolog D; cysteine protease ATG4D; AUT-like 4 cysteine endopeptidase; autophagin-4; autophagy-related cysteine endopeptidase 4; autophagy-related protein 4 homolog D (ATG4D APG4D AUTL4)

Function

• cysteine protease required for autophagy
• cleaves C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I
• a subpopulation of form I is subsequently converted to a smaller form (form II)
• form II, with a revealed C-terminal GLY, is considered to be the phosphatidylethanolamine-conjugated form, & has the capacity for the binding to autophagosomes

Inhibition:

• inhibited by N-ethylmaleimide

Structure

belongs to the peptidase C54 family

Compartment

cytoplasm (probable)

Expression

• mainly expressed in skeletal muscle
• expressed, to a lesser extent, in testis

More general terms

• autophagy protein (autophagy-related protein)
• cysteine proteinase; thiol proteinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84971
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84971
• OMIM: https://mirror.omim.org/entry/611340
• UniProt: http://www.uniprot.org/uniprot/Q86TL0.html