thioredoxin domain-containing protein 12; endoplasmic reticulum resident protein 18; ER protein 18; ERp18; endoplasmic reticulum resident protein 19; ER protein 19; ERp19; thioredoxin-like protein p19; hTLP19 (TXNDC12, TLP19, UNQ713/PRO1376)

Function

• possesses significant protein thiol-disulfide oxidase activity

Kinetic parameters:

• KM=25 uM for Asn-Arg-Cys-Ser-Gln-Gly-Ser-Cys-Trp-Asn
• pH dependence:
• optimum pH is 6.5

Structure

contains 1 thioredoxin domain

Compartment

endoplasmic reticulum lumen

Expression

widely expressed

More general terms

• thioredoxin-like protein
• thioredoxin domain-containing protein
• oxidoreductase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51060
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51060
• OMIM: https://mirror.omim.org/entry/609448
• UniProt: http://www.uniprot.org/uniprot/O95881.html