GPI ethanolamine phosphate transferase 3; phosphatidylinositol-glycan biosynthesis class O protein; PIG-O (PIGO)

Function

• ethanolamine phosphate transferase involved in GPI-anchor biosynthesis
• transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond
• glycolipid biosynthesis; GPI-anchor biosynthesis
• forms a complex with PIGF
• PIGF is required to stabilize PIGO (putative)

Structure

• belongs to the PIGG/PIGN/PIGO family, PIGO subfamily

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein (putative)

Alternative splicing

• named isoforms=2
• additional isoforms seem to exist

More general terms

• transmembrane 14 protein
• phosphatidylinositol-glycan biosynthesis protein (PIG-protein)
• glycoprotein

Additional terms

• phosphatidylinositol [PI] glycan

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84720
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84720
• UniProt: http://www.uniprot.org/uniprot/Q8TEQ8.html