LanC-like protein 2 (testis-specific adriamycin sensitivity protein, LANCL2, GPR69B, TASP)

Structure

belongs to the LanC-like protein family

Compartment

nucleus, cytoplasm, cell membrane

Expression

expressed in brain & testis

Pathology

• bystander coamplified & overexpressed with epidermal growth factor receptor (EGFR) in 20% of all glioblastomas
• exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P-glycoprotein 1) & increases cellular sensitivity to an anticancer drug adriamycin

More general terms

• LanC-like protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NS86.html