B-cell CLL/lymphoma 7 protein family member A (BCL7A)

Function

• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• bcl-7a shows homology to caldesmon
• belongs to the BCL7 family

Alternative splicing

named isoforms=2

Pathology

• the bcl-7a gene is a site of recurrent breakpoint in high grade B cell lymphomas
• chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) involving BCL7A, MYC & immunoglobulin gene region associated with B-cell non-Hodgkin lymphoma

More general terms

• bcl protein (B-cell leukemia/lymphoma protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=605
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:605
• OMIM: https://mirror.omim.org/entry/601406
• UniProt: http://www.uniprot.org/uniprot/Q4VC05.html