killer cell inhibitory receptor; killer cell immunoglobulin like receptor (KIR)

Introduction

one of two distinct groups of NK cell receptors: KIRs (immunoglobulin superfamily proteins) & NKG2 receptors (C-type lectin superfamily proteins)

Polymorphism

• the KIR genes are located in a segment of DNA on 19q13.4 in the leukocyte receptor complex that has undergone expansion & contraction over time, probably through unequal crossing-over; thus, KIR haplotypes vary in the number & types of genes, although a few framework loci, such as the gene KIR3DL1, are present on all or nearly all haplotypes

More general terms

• immunoglobulin superfamily protein

More specific terms

• CD158
• killer cell immunoglobulin like receptor 2D (KIR2D)
• killer cell immunoglobulin like receptor 3D (KIR3D)
• leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1, hLAIR1, CD305 antigen, LAIR1, CD305)
• leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2, CD306 antigen, LAIR2, CD306)

Additional terms

• killer cell lectin-like receptor C subfamily or NKG2 receptor