inactive serine/threonine protein kinase VRK3; serine/threonine protein pseudokinase VRK3; vaccinia-related kinase 3 (VRK3)

Function

• inactive kinase
• suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates & inactivates ERK in the nucleus
• interacts with DUSP3 (putative)
• interacts with RAN

Structure

• belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family, VRK subfamily
• contains 1 protein kinase domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Notes

• inactive as a kinase due to its inability to bind ATP

More general terms

• serine/threonine protein kinase VRK (Vaccinia-related kinase)
• nuclear protein

Additional terms

• vaccinia virus

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51231
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51231
• UniProt: http://www.uniprot.org/uniprot/Q8IV63.html