dual serine/threonine & tyrosine protein kinase; Dusty protein kinase; Dusty PK; RIP-homologous kinase; receptor-interacting serine/threonine protein kinase 5; sugen kinase 496; SgK496 (DSTYK, KIAA0472, RIP5, RIPK5, SGK496, HDCMD38P)

Function

• may induce apoptosis (caspase-dependent & caspase-independent)

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

cytoplasm

Alternative splicing

named isoforms=4

Expression

• predominantly expressed in skeletal muscle & testis
• weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord & adrenal gland
• widely distributed in the CNS
• detected in several tumor cell lines

More general terms

• receptor-interacting serine/threonine protein kinase (RIPK)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25778
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25778
• OMIM: https://mirror.omim.org/entry/612666
• UniProt: http://www.uniprot.org/uniprot/Q6XUX3.html