MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3, MAPKAP kinase 3, MAPKAPK-3, hromosome 3p kinase, 3pK, MAPKAPK3)

Function

• modulator of polycomb-mediated repression, which can be activated either by ERK, p38 & JNK
• substrate of CSBP
• in vitro, phosphorylates HSPB1, BMI1/PCGF4 & TCF3
• interacts with TCF3 & with polycomb proteins, such as PCH2 & BMI1/PCGF4

ATP + a protein <--> ADP + a phosphoprotein

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

• nucleus, cytoplasm
• predominantly located in the nucleus
• when activated, translocates to the cytoplasm

Expression

• widely expressed
• higher expression observed in heart & skeletal muscle
• no expression in brain

More general terms

• MAP kinase-activated protein kinase

Database

• OMIM: https://mirror.omim.org/entry/602130
• UniProt: http://www.uniprot.org/uniprot/Q16644.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7867