mitogen activated protein kinase kinse kinase kinase 6 (MAP4K6, MAPK/ERK kinase kinase kinase 6, MEK kinase kinase 6, MEKKK 6, misshapen/NIK-related kinase, GCK family kinase MiNK)

Function

• serine/threonine kinase
• may play a role in response to environmental stress
• appears to act upstream of the JUN N-terminal pathway
• may play a role in the development of the brain (putative)

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2 (putative)

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
• contains 1 CNH domain contains 1 protein kinase domain

Alternative splicing

named isoforms=3

Expression

• expressed in the brain
• isoform 2 is more abundant than isoform 1

More general terms

• mitogen activated protein kinase kinse kinase kinase

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N4C8.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50488