mitogen activated protein kinase kinse kinase kinase 5; MAP4K5; MEK kinase kinase 5; MEKKK 5; kinase homologous to SPS1/STE20 (KHS)

Function

• may play a role in the response to environmental stress
• appears to act upstream of the JUN N-terminal pathway
• interacts with both SH3 domains of the adapter proteins CRK & CRKL

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
• contains 1 CNH domain contains 1 protein kinase domain

Compartment

cytoplasm

Expression

• ubiquitously expressed in all tissues examined
• high expression in the ovary, testis & prostate

More general terms

• mitogen activated protein kinase kinse kinase kinase

Database

• OMIM: https://mirror.omim.org/entry/604923
• UniProt: http://www.uniprot.org/uniprot/Q9Y4K4.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11183